The Effect of an Annona muricata Leaves Extract on Circulating Soluble Adhesion Molecules in Colon Carcinogenesis Model

Authors

  • Lili Indrawati Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta
  • Kusmardi Kusmardi Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
  • Marwito Wiyanto Department of Physiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta

DOI:

https://doi.org/10.24871/241202330-34

Keywords:

Annona muricata, ICAM-1, VCAM-1, colon carcinogenesis, in vivo

Abstract

Background: Annona muricata leaves are used as traditional tea drink that is currently being studied on the developing effort of treating some types of cancers because they are known as anti-cancer. Motivated by that usage, this study aims to analyse the potential of A. muricata leaves extract to be an anti-colon cancer by investigating the extract capability in reducing blood intercellular cell-adhesion molecule-1 (ICAM-1) and vascular cell-adhesion molecule-1 (VCAM-1).

Method: The research was conducted in Faculty of Medicine Universitas Indonesia with an ex­perimental design. A. muricata leaves extract was tested in vivo. In vivo test was conducted to Swiss Webster mice induced with 10 mg/kg azoxymethane (AOM) and dextran sodium sulfate 1% (DSS). Statistical analysis used was SPSS.

Results: EIFAM reduce the serum level of ICAM-1 and VCAM-1. EIFAM significantly reduce serum level of VCAM compare to ESFAM.

Conclusion: Ethanol insoluble fraction of Annona muricata leaves water extract of is potential to be an anti-colon cancer proven by the extract capability to reduce ICAM-1 and VCAM-1.

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Published

2023-04-10

How to Cite

Indrawati, L., Kusmardi, K., & Wiyanto, M. (2023). The Effect of an Annona muricata Leaves Extract on Circulating Soluble Adhesion Molecules in Colon Carcinogenesis Model. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 24(1), 30–34. https://doi.org/10.24871/241202330-34

Issue

Vol. 24 No. 1 (2023): VOLUME 24, NUMBER 1, April, 2023

Section

Original Articles

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