Correlation between the Eosinophil Colonic Mucosa Density and Severity of Ulcerative Colitis

Authors

  • Nisma Aulia Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta
  • Deshinta Putri Mulya Division of Allergy Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta
  • Putut Bayupurnama Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta
  • Neneng Ratnasari Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta

DOI:

https://doi.org/10.24871/2422023132-136

Keywords:

ulcerative colitis, colonic mucosal eosinophils, eosinophilia, Truelove Witts score

Abstract

Background: The inflammatory process of ulcerative colitis (UC) involves eosinophils. Eosinophils are not only related to the severity of UC but also to clinical improvement. The role of eosinophils in colonic mucosa has not been fully understood. This study aims to determine the correlation between the density of eosinophils in the colonic mucosa and the severity of ulcerative colitis.

Method: This is a prospective cross-sectional study with consecutive sampling between August 2020 and July 2021. The subjects were UC inpatients/outpatients at Dr. Sardjito Hospital who met the inclusion and exclusion criteria. The number and location of the biopsies are determined based on a colonoscopy performed by a Gastroenterology-Hepatology Consultant. An Anatomic Pathology Specialist examined the eosinophil colonic tissue. The severity of UC was classified using the Truelove Witts score. Data analysis using a computer program with a p-value < 0.05 was considered statistically significant.

Results: There are 3 UC severity categories according to the Truelove Witts score: 22 mild (45.8%), 9 moderate (18.8%), and 17 severe (35.4%). Seven participants (14.6%) had eosinophilia, with a median eosinophilia score of 203.33 cells/microL (0–1470 cells/microL). Five participants (10.4%) with colonic mucosal eosinophilia, with a median value of 14.13 cells/HPF (0–172 cells/HPF). The density of colonic mucosal eosinophils and the severity of UC had a moderate connection (r = 0.396; p = 0.005).

Conclusion: There is a significant correlation between the density of eosinophils in the colonic mucosa and the severity of UC.

Author Biography

Nisma Aulia, Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta

Nisma Aulia, MD is a young staff in Gastroenterohepatology Division, Internal Medicine Department, Gadjah Mada University, Dr. Sardjito Hospital. Graduated from Internal Medicine Specialist Program at Gadjah Mada University in the year 2022. Currently, working as an Internist in Internal Medicine Department, Dr. Sardjito Hospital. Have been awarded a Presenting Author for The Best Paper on Medical Student Category in Jogja Liver Cirrhosis Forum 2012, Yogyakarta, Indonesia. Also presented 3 papers in Local & International Forum.

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Published

2023-11-24

How to Cite

Aulia, N., Mulya, D. P., Bayupurnama, P., & Ratnasari, N. (2023). Correlation between the Eosinophil Colonic Mucosa Density and Severity of Ulcerative Colitis. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 24(2), 132–136. https://doi.org/10.24871/2422023132-136

Issue

Vol. 24 No. 2 (2023): VOLUME 24, NUMBER 2, August, 2023

Section

Original Articles

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