Asparaginase-Induced Acute Necrotizing Pancreatitis Resulting in Chronic Pancreatitis and Pseudocyst in an Adult with Acute Lymphocytic Leukemia

Authors

  • Randy Adiwinata Department of Internal Medicine, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado
  • Bradley Jimmy Waleleng Division of Gastroenterology-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado
  • Harlinda Haroen Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado
  • Linda Rotty Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado
  • Fandy Gosal Division of Gastroenterology-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado
  • Luciana Rotty Division of Gastroenterology-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado
  • Cecillia Hendratta Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado
  • Pearla Lasut Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado
  • Jeanne Winarta Division of Gastroenterology-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado
  • Andrew Waleleng Division of Gastroenterology-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado
  • Michael Tendean Division of Digestive Surgery, Department of Surgery, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R.D. Kandou General Hospital, Manado

DOI:

https://doi.org/10.24871/241202398-101

Keywords:

pancreatitis, acute lymphocytic leukemia, asparaginase

Abstract

L-Asparaginase is one of the main chemotherapy regiments for acute lymphocytic leukemia (ALL) management. Acute pancreatitis is one of the serious side effects of l-asparaginase administration and may lead to interruption of chemotherapy cycle. Long term complications may be devastating for patients which include of pseudocyst pancreas and chronic pancreatitis. Asparaginase induced pancreatitis is rare among adult due to the nature of ALL which commonly occurred in children population. The pathophysiology of asparaginase induced pancreatitis is still unclear. Here we present 18-year-old male with ALL and asparaginase induced acute necrotizing pancreatitis which complicated to chronic pancreatitis and pseudocyst. 

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Published

2023-04-10

How to Cite

Adiwinata, R., Waleleng, B. J., Haroen, H., Rotty, L., Gosal, F., Rotty, L., … Tendean, M. (2023). Asparaginase-Induced Acute Necrotizing Pancreatitis Resulting in Chronic Pancreatitis and Pseudocyst in an Adult with Acute Lymphocytic Leukemia. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 24(1), 98–101. https://doi.org/10.24871/241202398-101

Issue

Vol. 24 No. 1 (2023): VOLUME 24, NUMBER 1, April, 2023

Section

Case Reports

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