New Paradigm of Gastric Pathogenesis: The Important Role of Gastric Microbiota

Authors

  • Muhammad Miftahussurur Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya
  • Camilia Metadea Aji Savitri Institute of Tropical Disease, Universitas Airlangga, Surabaya
  • Reny I'tishom Department of Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya
  • Purwo Sri Rejeki Department of Physiology, Faculty of Medicine, Universitas Airlangga, Surabaya
  • Yudith Annisa Ayu Rezkitha Department of Internal Medicine, Faculty of Medicine, Universitas Muhammadiyah Surabaya, Surabaya
  • Yoshio Yamaoka Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya

DOI:

https://doi.org/10.24871/231202262-66

Keywords:

microbiota, gastric diseases, H. pylori, stomach, cancer, infectious disease

Abstract

Microbiota was deemed essential as it involved in energy metabolism, nutrient absorption, intestinal immune system maturation, and pathogen protection. Gastrointestinal microbiome played essential roles in human body, such as immune response regulation, pathogen colonization, and few other diseases.  The relation between gastric microbiota and host were difficult to explore for years due to unculturable microbes. Stomach with its acid production was presumed to be sterile and unfavorable for bacterial growth until the discovery of Helicobacter pylori. It dominates the stomach as it was estimated to colonize almost 50% global population. H. pylori infection was linked to the development of chronic gastritis and recognized as a definite carcinogen. There was a probability that the alteration of gastric microbiota likely influenced gastric immunobiology and possible gastric diseases. Recent studies showed that five phyla consist of Firmicutes, Bacteroidetes, Actinobacteria, Fusobacteria and Proteobacteria have been discovered in stomach mucosa which might contribute to the pathological process. In addition, genera such as Lactobacillus, Escherichia-Shigella, Lachnospiraceae, Burkholderia and Nitrospirae were considered to have a role on gastric carcinogenesis.

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Published

2022-05-15

How to Cite

Miftahussurur, M., Savitri, C. M. A., I’tishom, R., Rejeki, P. S., Rezkitha, Y. A. A., & Yamaoka, Y. (2022). New Paradigm of Gastric Pathogenesis: The Important Role of Gastric Microbiota. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 23(1), 62–66. https://doi.org/10.24871/231202262-66

Issue

Vol. 23 No. 1 (2022): VOLUME 23, NUMBER 1, April 2022

Section

Review Article

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