C-Reactive Protein and Interleukin-6 Correlated with Resistin Level in Liver Cirrhosis

I Ketut Mariadi(1), Hendra Koncoro(2), I Dewa Nyoman Wibawa(3),


(1) Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar
(2) Department of Internal Medicine, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital, Denpasar
(3) Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital, Denpasar
Corresponding Author

Abstract


Background: The incidence of insulin resistance is very high in liver cirrhosis. Resistin is thought to be one of the factors contributing to the occurrence of insulin resistance. Liver Cirrhosis is a chronic inflammatory condition. C-reactive protein (CRP) and interleukin-6 (IL-6) are inflammatory mediators, which are associated with the severity of liver damage. Resistin also increases in liver cirrhosis. This study aimed to determine whether CRP and IL-6 levels were correlated with resistin levels in patients with liver cirrhosis.

Method: An analytic cross-sectional study was conducted, in cirrhosis patients, to determine CRP and IL-6 levels as markers of the inflammatory process and blood resistin levels.

Results: In this study was found, CRP and IL-6 levels were associated with the severity of liver cirrhosis. Resistin levels are associated with the severity of cirrhosis of the liver. CRP and IL-6 levels are positively correlated with resistin levels and as independent predictors of resistin levels.

Conclusion: This study concluded that CRP and IL-26 levels are correlated with resistin levels and as independent predictors of resistin levels in liver cirrhosis patients.


Keywords


Resistin; C-reactive protein (CRP); interleukin-6 (IL-6); liver cirrhosis

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DOI: 10.24871/211202017-21

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