Gastric Mucosa Plasma Cells is Unspecific for Diagnosing Helicobacter pylori Infection

Authors

  • Gilda Hartecia Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya
  • Willy Sandhika Department of Anatomic Pathology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya
  • Ummi Maimunah Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya
  • Muhammad Miftahussurur Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya

DOI:

https://doi.org/10.24871/202201982-86

Keywords:

Helicobacter pylori, plasma cell, antibody, gastric mucosa, chronic gastritis

Abstract

Background: A high density of Helicobacter pylori is believed to trigger an accumulation of plasma cells in the gastric mucosa. This accumulation stimulated the production of antibodies, causing high antibodies titer being circulated in the blood. The aims of this study is to identify the correlation between the number of plasma cells and H. pylori density in gastric mucosa.

Method: This observational analytic study was performed with cross-sectional approach. The samples were the paraffin blocks which consisted of endoscopic gastric biopsy tissues of chronic gastritis patient in Anatomic Pathology Laboratory Dr. Soetomo General Hospital Surabaya in 2017 period. A total of 30 samples were purposively collected. Endoscopic gastric biopsy tissues were stained by two stains, Haematoxylin-Eosin and Modified Giemsa. The examination was performed by experienced pathologist. The correlation between total plasma cells and H. pylori density in gastric mucosa and the difference of total plasma cells between gastric mucosae with different density of H. pylori were determined.

Results: There was no significant correlation between total plasma cells and H. pylori density in gastric mucosa. And there was no significant difference of the number of plasma cells found with different density of H. pylori.

Conclusion: The number of plasma cells in the gastric mucosa is unspecific for diagnosing H. pylori infection. Other causes associated with plasma cells need to be assessed in further studies.

Downloads

Published

2020-07-23

How to Cite

Hartecia, G., Sandhika, W., Maimunah, U., & Miftahussurur, M. (2020). Gastric Mucosa Plasma Cells is Unspecific for Diagnosing Helicobacter pylori Infection. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 20(2), 82–86. https://doi.org/10.24871/202201982-86

Issue

Vol. 20 No. 2 (2019): VOLUME 20, NUMBER 2, August 2019

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).