Probiotics as Alternative Therapy for Psychometric Disorders in Hepatic Encephalopathy

Authors

  • Bany Faris Amin Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
  • Irfan Kresnadi Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
  • Vannessa Karenina Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
  • GM Yudi Prasetia A Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
  • Trivani Putri Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
  • Juferdy Kurniawan Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Jakarta

DOI:

https://doi.org/10.24871/201201948-53

Keywords:

Hepatic encephalopathy, lactulose, number connection test (NCT), probiotic

Abstract

Aim: To identify whether probiotics have the same effectiveness as lactulose in improving the results of psychometric testing in patients with hepatic encephalopathy.

Method: Literature Searching were performed on Pubmed, EBSCOhost, Scopus, and Cochrane databases to obtain an randomized controlled trial (RCT) or a systematic review. Searches were made with the keywords "hepatic encephalopathy", "probiotic", "lactulose" and number connection test  ("NCT").  Search is continued by excluding the literature through abstract and full text.

Results: Two studies were found to be relevant according to the criteria. The study by Mittal showed that probiotics were better than lactulose in improving NCT-B with a risk ratio (RR) of 0.88 (95% CI: 0.54-1.44; p = 0.62) but not better for improving NCT- A with RR 1.43 (95% CI: 0.62-3.24; p = 0.40). In the Sharma study, lactulose was better in improving NCT score with the mean difference (MD) 6.7 (95% CI: 0.58-12.82) and in the Li study, there was no significant significance between MD 3.93 (95% CI: -0,72-8,58)

Conclusion: In conclusion, Probiotics cannot replace lactulose as a standard therapy for hepatic encephalopathy. There is not enough evidence that proves probiotics are better than lactulose.

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Published

2020-07-22

How to Cite

Amin, B. F., Kresnadi, I., Karenina, V., Prasetia A, G. Y., Putri, T., & Kurniawan, J. (2020). Probiotics as Alternative Therapy for Psychometric Disorders in Hepatic Encephalopathy. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 20(1), 48–53. https://doi.org/10.24871/201201948-53

Issue

Vol. 20 No. 1 (2019): VOLUME 20, NUMBER 1, April 2019

Section

Case Reports

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