Long Term Risks of Proton Pump Inhibitor Administration: A Literature Review

Authors

  • Andi Kristanto
  • Randy Adiwinata
  • Josephin Rasidi
  • Beatrice Belinda Phang
  • Sheila Adiwinata
  • Timoteus Richard
  • Willy Brodus Uwan
  • Ari Fahrial Syam

DOI:

https://doi.org/10.24871/1832017169-176

Keywords:

Proton pump inhibitor, long term side effect, polyp, infection, dementia, malabsorption, osteoporosis, chronic kidney disease, cardiovascular

Abstract

Proton pump inhibitor (PPI) has become drug of choice for acid related disease. However, PPI tend to be overprescribed and becoming one of the highest burden for health cost. Some studies showed that PPI are prescribed unnecessarily. Recent evidences showed raised concerns over long term effects of PPI consumption. Several long term side effects such as increased incidence of gastric polyps, micronutrient absorption disorders, infections, and osteoporosis have been yearly discussed. In recent years there has been increased attention to new side effects such as dementia, chronic renal failure, and cardiovascular disorders. Therefore, some health associations had issued warning and guidance regarding long term PPI prescription.

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Published

2020-07-19

How to Cite

Kristanto, A., Adiwinata, R., Rasidi, J., Phang, B. B., Adiwinata, S., Richard, T., … Syam, A. F. (2020). Long Term Risks of Proton Pump Inhibitor Administration: A Literature Review. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 18(3), 169–176. https://doi.org/10.24871/1832017169-176

Issue

Vol. 18 No. 3 (2017): VOLUME 18, NUMBER 3, DECEMBER 2017

Section

Review Article

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