Correlation Between Serum Thrombopoietin Level and Cirrhosis Clinical Stage in Liver Cirrhosis Patients in Mohammad Hoesin Palembang Hospital and Palembang BARI Hospital

Authors

  • Muhamad Ayus Astoni Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sriwijaya/Dr. Mohammad Hoesin Hospital, Palembang
  • Fuad Bakry Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sriwijaya/Dr. Mohammad Hoesin Hospital, Palembang
  • Irsan Saleh Department of Biomedical, Faculty of Medicine, University of Sriwijaya, Palembang

DOI:

https://doi.org/10.24871/1632015153-159

Keywords:

liver cirrhosis, thrombopoietin (TPO), Child-Pugh classification

Abstract

Background: Thrombopoietin (TPO) is a cytokine mainly produced in the liver that regulate humoral control mechanism of thrombopoesis. Presumably, TPO production is decrease in patients with liver cirrhosis which interfere platelet production. The aim of this study was to identify the correlation between serum TPO levels and the clinical stage of liver cirrhosis.

Method: With analytical cross sectional design, this sudy analyzed the correlation between the serum TPO level and the clinical stage of liver cirrhosis according to Child-Pugh classification in 32 liver cirrhosis patients and 30 healthy subjects from March 2015 to August 2015. The serum level of TPO was examined using the Quantikine human TPO immunoassay.

Results: There were 13 females and 19 males patients aged 19 to 67 years old. Serum TPO level were lower in patients with liver cirrhosis (65.65 ± 28.97 pg/mL) than in healthy subjects (98.16 ± 41.25 pg/mL, p < 0.005). Serum TPO levels were negatively correlated with clinical stage of liver cirrhosis in a moderate strength of correlation (r = -0.516, p = 0.002). There were no correlation between serum TPO level and platelet count (r = 0.186; p = 0.309), but a significant negative correlation between the clinical stage of liver cirrhosis and platelet counts (r = - 0.361; p = 0.042).

Conclusion: There was a significant negative correlation between serum TPO levels and the clinical stage of liver cirrhosis according to Child-Pugh classification.

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Published

2015-12-01

How to Cite

Astoni, M. A., Bakry, F., & Saleh, I. (2015). Correlation Between Serum Thrombopoietin Level and Cirrhosis Clinical Stage in Liver Cirrhosis Patients in Mohammad Hoesin Palembang Hospital and Palembang BARI Hospital. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 16(3), 153–159. https://doi.org/10.24871/1632015153-159

Issue

Vol. 16 No. 3 (2015): VOLUME 16, NUMBER 3, December 2015

Section

Original Articles

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