Correlation between Serum Albumin and Fasting Blood Glucose Level in Patients with Liver Cirrhosis

Authors

  • Nenny Agustanti Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, University of Padjadjaran/Hasan Sadikin General Hospital, Bandung
  • Ali Djumhana Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, University of Padjadjaran/Hasan Sadikin General Hospital, Bandung
  • Siti Aminah Abdurachman Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, University of Padjadjaran/Hasan Sadikin General Hospital, Bandung
  • Soetodjo NMN Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Padjadjaran/Hasan Sadikin General Hospital, Bandung

DOI:

https://doi.org/10.24871/1532014143-146

Abstract

Background: Liver cirrhosis is a pathological condition describes the end-stage of liver fibrosis. On liver damage may occur impaired glucose metabolism such as insulin resistance and glucose intolerance. The correlation between chronic liver diseases with impaired glucose metabolism has been known as hepatogenous diabetes. Albumin levels were significantly affected by poorly controlled blood glucose seen from the high HbA1c. This study aims to determine correlation of serum albumin level and fasting blood glucose level in patients with liver cirrhosis.

Method: This cross-sectional study was conducted in 52 patients with liver cirrhosis in Gastroentero-hepatology Clinic and Inpatients, Hasan Sadikin Hospital. The study was conducted from February to June 2013. History taking, physical examination and laboratory tests including liver function tests and fasting blood glucose were performed. Data were analyzed using Spearman rank test for the correlation.

Results: There were 31 (59.6%) males and 21 (40.4%) females with mean age 53.4 ± 12.8 years. The mean serum albumin was 2.7 ± 0.5 g/dL and median fasting blood glucose was 100 (66-195) mg/dL. Etiology of liver cirrhosis was hepatitis B virus infection 28 (51.9%), hepatitis C virus infection 16 (30.8%) and non viral hepatitis B and C infection 9 (17.3%). Severity of cirrhosis scored using child turcotte pugh (CTP) which was 43 (82.7%) of CTP B and 9 (17.3%) of CTP C. There was statistically significant correlation between albumin level and fasting blood glucose with ρ = -0.630 and p < 0.01.

Conclusion: In patients with liver cirrhosis have low serum albumin level correlates with high fasting blood glucose.

 

Keywords: cirrhosis, albumin, fasting blood glucose

Downloads

Published

2014-12-01

How to Cite

Agustanti, N., Djumhana, A., Abdurachman, S. A., & NMN, S. (2014). Correlation between Serum Albumin and Fasting Blood Glucose Level in Patients with Liver Cirrhosis. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 15(3), 143–146. https://doi.org/10.24871/1532014143-146

Issue

Vol. 15 No. 3 (2014): VOLUME 15, NUMBER 3, December 2014

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).