S-Index and APRI Score to Predict Liver Fibrosis Chronic in Hepatitis B and C Patients

Authors

  • Elias Tarigan
  • Leonardo Basa Dairy
  • Juwita Sembiring
  • Mabel Sihombing
  • Gontar Alamsyah Siregar
  • Lukman Hakim Zain

DOI:

https://doi.org/10.24871/142201364-68

Abstract

Background: A great interest has been dedicated to the development of non invasive predictive models in recent years to substitute liver biopsy for fibrosis assessment and follow-up. The aim of this study was to compare
the accuracy between S-index and aspartate aminotransferase to platelet ratio index (APRI) to FibroScan for predicting liver fibrosis in chronic hepatitis B and C patients.

Method: A cross-sectional study was conducted in 40 patients with chronic hepatitis B and C between January 2010 - May 2011 at Division of Gastroentero-hepatology, Department of Internal Medicine, Adam Malik Hospital, Medan. Patients underwent laboratory examination and FibroScan, then used predictive values to assess the accuracy of S-index scores and APRI compared to FibroScan. The analysis was performed using SPSS 15.0.

Results: S-index identified significant fibrosis in 87.5% patients with sensitivity (Se) 87.5% and specificity (Sp) 100%. About 67.5% of 40 patients could be identified correctly. S-index also could accurately predict the absence or presence of cirrhosis in 87.5% of the total 40 patients, with NPV 91.7% and PPV 81.25%, respectively. APRI for significant fibrosis has Se 85.7%, Sp 88%, PPV 88.8%, NPV 69.2%; while Se 53%, Sp 88%, PPV 72.7%, NPV 75.8% for liver cirrhosis. AUROC value for S-index was higher than APRI in predicting significant fibrosis and cirrhosis, i.e. 0.938 vs. 0.917 and 0.873 and 0.707, respectively.

Conclusion: The S-index has a higher accuracy than APRI in predicting significant fibrosis and cirrhosis in patients with chronic hepatitis B virus and hepatitis C virus infection.

Keywords: S-index, APRI score, FibroScan, chronic hepatitis B and C

Downloads

Published

2013-09-19

How to Cite

Tarigan, E., Dairy, L. B., Sembiring, J., Sihombing, M., Siregar, G. A., & Zain, L. H. (2013). S-Index and APRI Score to Predict Liver Fibrosis Chronic in Hepatitis B and C Patients. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 14(2), 64–68. https://doi.org/10.24871/142201364-68

Issue

VOLUME 14, NUMBER 2, August 2013

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).