Laboratorium Diagnosis of Clostridium difficile Infection

Authors

  • Grace Nerry Legoh
  • Rustadi Sosrosumihardjo

DOI:

https://doi.org/10.24871/72200646-50

Abstract

Clostridium difficile is the most important cause of antibiotic associated diarrhea, and pseudomembranous colitis, a severe infection of the colon. Strain Clostridium difficile produce two potent toxin, toxin A (enterotoxin) and toxin B (cytotoxin). These two toxins are both responsible for the diarrhoea and inflammation seen in patients treated due to infection, especially the broad spectrum antibiotics. Direct detection of Clostridium difficile cytotoxin from faecal specimen using mammalian tissue culture lines is considered the standard diagnostics test of Clostridium difficile infection. This test is very sensitive but requires a minimum two days to complete. In order to improve the threshold of diagnosis and treatment, a number of enzyme immunoassay
Methods have been used, with a reported sensitivity to either toxin A or toxin B.
Keywords: Clostridium difficile, cytotoxin, diarrhea, enzyme immunoassay
VOLUME 7, ISSUE 2, August 2006

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Published

2006-01-08

How to Cite

Legoh, G. N., & Sosrosumihardjo, R. (2006). Laboratorium Diagnosis of Clostridium difficile Infection. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 7(2), 46–50. https://doi.org/10.24871/72200646-50

Issue

VOLUME 7, ISSUE 2, August 2006

Section

Review Article

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